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Spatial modulation of visual responses arises in cortex with active navigation

Citation

Diamanti, Efthymia (Mika) et al. (2021), Spatial modulation of visual responses arises in cortex with active navigation, Dryad, Dataset, https://doi.org/10.5061/dryad.4j0zpc893

Abstract

During navigation, the visual responses of neurons in mouse primary visual cortex (V1) are modulated by the animal’s spatial position. Here we show that this spatial modulation is similarly present across multiple higher visual areas but negligible in the main thalamic pathway into V1. Similar to hippocampus, spatial modulation in visual cortex strengthens with experience and with active behavior. Active navigation in a familiar environment, therefore, enhances the spatial modulation of visual signals starting in the cortex.

Methods

2 photon imaging

Raw data were preprocessed with Suite2p (image registration, ROI detection, deconvolution)

Corrected traces were used for estimating response profile patterns as described in Methods and in Readme file.

Usage Notes

Plese see the Readme file for full description of the datasets and any additional notes.

Funding

Engineering and Physical Sciences Research Council, Award: F500351/1351

Wellcome Trust, Award: Royal Society 200501

Human Frontiers in Science, Award: RGY0076/2018

Wellcome Trust, Award: 205093

Human Frontiers in Science, Award: RGY0076/2018