Data from: Ultra structural changes occurring in duct ectasia and periductal mastitits and their significance in etiopathogenesis
Ramalingam, Kirithiga et al. (2018), Data from: Ultra structural changes occurring in duct ectasia and periductal mastitits and their significance in etiopathogenesis, Dryad, Dataset, https://doi.org/10.5061/dryad.528tv
Introduction: Duct Ectasia (DE) and Periductal Mastitis (PDM) are the most common benign breast conditions seen in women. The etiopathogenesis of these entities is still not clear and most of the theories regarding the causation are based on the histological features as seen on light microscopy. The ultramicroscopic features associated with these conditions that may give more insight to the etiopathogenesis are unknown. Aim: To study the ultrastructural changes occurring in mammary duct cones in patients with DE and PDM using Transmission Electron Microscopic (TEM). Method: Major ducts removed by radical duct excision from 21 patients with final histopathological diagnosis of DE and PDM were subjected to TEM study with 2 normal duct samples as controls Results: The TEM features of DE were denudation of the epithelial cells with focal loss of microvilli, widening of the inter-epithelial junctions with focal disruption of the T bars, periductal collagenisation without inflammation; and features suggestive of Epithelial Mesenchymal Transition (EMT). PDM features are intact epithelial lining with proliferative epithelium and periductal collagenisation with inflammation. Conclusions: Based on the TEM findings, we suggest that DE and PDM are two different entities. EMT is a novel finding observed in DE in this study.