Data from: Alterations of gray and white matter networks in patients with obsessive-compulsive disorder: a multimodal fusion analysis of structural MRI and DTI using mCCA+jICA
Kim, Seung-Goo, Seoul National University Hospital, Max Planck Institute for Human Cognitive and Brain Sciences
Jung, Wi Hoon, Seoul National University Hospital
Kim, Sung Nyun, Seoul National University
Jang, Joon Hwan, Seoul National University
Kwon, Jun Soo, Seoul National University Hospital
Published Apr 24, 2016 on Dryad.
Cite this dataset
Kim, Seung-Goo et al. (2016). Data from: Alterations of gray and white matter networks in patients with obsessive-compulsive disorder: a multimodal fusion analysis of structural MRI and DTI using mCCA+jICA [Dataset]. Dryad. https://doi.org/10.5061/dryad.5jv56
Many of previous neuroimaging studies on neuronal structures in patients with obsessive-compulsive disorder (OCD) used univariate statistical tests on unimodal imaging measurements. Although the univariate methods revealed important aberrance of local morphometry in OCD patients, the covariance structure of the anatomical alterations remains unclear. Motivated by recent developments of multivariate techniques in the neuroimaging field, we applied a fusion method called “mCCA+jICA” on multimodal structural data of T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of 30 unmedicated patients with OCD and 34 healthy controls. Amongst six highly correlated multimodal networks (p < 0.0001), we found significant alterations of the interrelated gray and white matter networks over occipital and parietal cortices, frontal interhemispheric connections and cerebella (False Discovery Rate q ≤ 0.05). In addition, we found white matter networks around basal ganglia that correlated with a subdimension of OC symptoms, namely ‘harm/checking’ (q ≤ 0.05). The present study not only agrees with the previous unimodal findings of OCD, but also quantifies the association of the altered networks across imaging modalities.
Preprocessed MR images, demographics and clinical assessments
You can find preprocessed magnetic resonance (MR) images, demographics of 30 patients with obsessive-compulsive disorder (OCD) and 34 age-/sex-matched healthy controls that were analyzed in the original article. Clinical assessments of Y-BOCS (Yale-Brown obsessive-compulsive scale) for the patients are included in the file.