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Data from: Contrasting patterns of selection and drift between two categories of immune genes in prairie-chickens

Citation

Bateson, Zachary W.; Whittingham, Linda A.; Johnson, Jeff A.; Dunn, Peter O. (2015), Data from: Contrasting patterns of selection and drift between two categories of immune genes in prairie-chickens, Dryad, Dataset, https://doi.org/10.5061/dryad.603hs

Abstract

Immune-receptor genes of the adaptive immune system, such as the major histocompatibility complex (MHC), are involved in recognizing specific pathogens and are known to have high rates of adaptive evolution, presumably as a consequence of rapid coevolution between hosts and pathogens. In contrast, many ‘mediating’ genes of the immune system do not interact directly with specific pathogens and are involved in signaling (e.g., cytokines) or controlling immune cell growth. As a consequence, we might expect stronger selection at immune-receptor than mediating genes, but these two types of genes have not been compared directly in wild populations. Here, we tested the hypothesis that selection differs between MHC (class I and II) and mediating genes by comparing levels of population differentiation across the range of greater prairie-chickens (Tympanuchus cupido). As predicted, there was stronger population differentiation and isolation-by-distance at immune-receptor (MHC) than at either mediating genes or neutral microsatellites, suggesting a stronger role of local adaptation at the MHC. In contrast, mediating genes displayed weaker differentiation between populations than neutral microsatellites, consistent with selection favoring similar alleles across populations for mediating genes. In addition to selection, drift also had a stronger effect on immune-receptor (MHC) than mediating genes as indicated by the stronger decline of MHC variation in relation to population size. This is the first study in the wild to show that the effects of selection and drift on immune genes vary across populations depending on their functional role.

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