Data from: Activity patterns of serotonin neurons underlying cognitive flexibility
Data files
Mar 01, 2018 version files 2.01 GB
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Data_info.m
33.58 KB
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hf3_ARC_alldata.mat
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hf3_BOH_alldata.mat
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hf3_D10_alldata.mat
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hf3_D11_alldata.mat
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hf3_D12_alldata.mat
482.23 KB
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hf3_DR1_alldata.mat
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hf3_DR2_alldata.mat
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hf3_DR3_alldata.mat
498.24 KB
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hf3_DR4_alldata.mat
506.33 KB
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hf3_DR5_alldata.mat
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hf3_DR6_alldata.mat
521.70 KB
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hf3_DR7_alldata.mat
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hf3_DR8_alldata.mat
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hf3_DR9_alldata.mat
502.63 KB
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hf3_GAL_alldata.mat
92.34 MB
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hf3_IDK_alldata.mat
101.73 MB
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hf3_KKK_alldata.mat
99.47 MB
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hf3_LAG_alldata.mat
107.11 MB
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hf3_MAX_alldata.mat
138.19 MB
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hf3_NAS_alldata.mat
89.14 MB
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hf3_NEW_alldata.mat
145.99 MB
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hf3_OHM_alldata.mat
161.03 MB
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hf3_ORE_alldata.mat
97.26 MB
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hf3_PAS_alldata.mat
126.45 MB
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hf3_POI_alldata.mat
97.41 MB
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hf3_QQQ_alldata.mat
167.65 MB
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hf3_RIE_alldata.mat
159.30 MB
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hf6_GAL_alldata.mat
48.82 MB
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hf6_IDK_alldata.mat
42.64 MB
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hf6_KKK_alldata.mat
48 MB
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hf6_LAG_alldata.mat
50.62 MB
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hf6_NAS_alldata.mat
43.26 MB
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hf6_ORE_alldata.mat
48.46 MB
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hf6_POI_alldata.mat
46.02 MB
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README_for_Data_info.txt
2.24 KB
Abstract
Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhanced plasticity. We used long-term photometric recordings in mice to study a population of dorsal raphe serotonin neurons, whose activity we could link to normal reversal learning using pharmacogenetics. We found that these neurons are activated by both positive and negative prediction errors, and thus report signals similar to those proposed to promote learning in conditions of uncertainty. Furthermore, by comparing the cue responses of serotonin and dopamine neurons, we found differences in learning rates that could explain the importance of serotonin in inhibiting perseverative responding. Our findings show how the activity patterns of serotonin neurons support a role in cognitive flexibility, and suggest a revised model of dopamine–serotonin opponency with potential clinical implications.