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Directional epistasis is common in morphological divergence

Bourg, Salomé1; Bolstad, Geir H.2; Griffin, Donald V.3; Pélabon, Christophe1; Hansen, Thomas F.4

Published Mar 07, 2024 on Dryad. https://doi.org/10.5061/dryad.66t1g1k7m

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Mar 07, 2024 version files 601.51 KB

Abstract

Epistasis is often portrayed as unimportant in evolution. While random patterns of epistasis may have limited effects on the response to selection, systematic directional epistasis can have substantial effects on evolutionary dynamics. Directional epistasis occurs when allelic substitutions that change a trait also modify the effects of allelic substitutions at other loci in a systematic direction. In this case, trait evolution may induce correlated changes in allelic effects and effective genetic variance (evolvability) that modify further evolution. Although theory thus suggests a potentially important role for directional epistasis in evolution, we still lack empirical evidence about its prevalence and magnitude. Using a new framework to estimate systematic patterns of epistasis from line-crosses experiments, we quantify its effects on 197 size-related traits from diverging natural populations in 24 animal and 17 plant species. We show that directional epistasis is common and tends to become stronger with increasing morphological divergence. In animals, most traits displayed negative directionality toward larger size, suggesting that epistasis constraints reducing evolvability toward larger size may be common. Dominance was also common and did not systematically alter the effects of epistasis.