Data from: FOXP2 exhibits neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
Kast, Ryan J., University of Southern California
Lanjewar, Alexandra L., University of Southern California
Smith, Colton D., University of Southern California
Levitt, Pat, University of Southern California
Published May 17, 2019 on Dryad.
Cite this dataset
Kast, Ryan J.; Lanjewar, Alexandra L.; Smith, Colton D.; Levitt, Pat (2019). Data from: FOXP2 exhibits neuron class specific expression, but is not required for multiple aspects of cortical histogenesis [Dataset]. Dryad. https://doi.org/10.5061/dryad.6hd7bf7
The expression patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been described, and some studies have tested the role of this protein in the development and function of specific forebrain circuits by diverse methods and in multiple species. Clinically, mutations in FOXP2 are associated with severe developmental speech disturbances, and molecular studies indicate that impairment of Foxp2 may lead to dysregulation of genes involved in forebrain histogenesis. Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized. Additionally, Foxp2 was removed from the developing mouse cortex at different prenatal ages using two Cre-recombinase driver lines. Detailed molecular and circuit analyses were undertaken to identify potential disruptions of development. Surprisingly, the results demonstrate that Foxp2 function is not required for many function s that it has been proposed to regulate, and therefore plays a more limited role in cortical development than previously thought.
This excel spreadsheet contains the raw numbers for all quantitative data included in the manuscript. The excel file is organized into sheets that contain data pertaining to different experiments and that are titled according to the manuscript figures in which the data appear.