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Dryad

Dermal collagen fiber data for Fiber Classification by ResNet

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Jan 28, 2025 version files 4.07 MB

Abstract

Type I collagen is a major component of the dermis and is formed by dermal fibroblasts. The development of dermal collagen structures has not been fully elucidated despite the major presence and importance of the dermis. This Lack of understanding is due in part to the opacity of mammalian skin and it has been an obstacle to cosmetic and medical developments. We succeeded in revealing the process of dermal collagen formation using the highly transparent skin of the axolotl and fluorescent collagen probes. We clarified that epidermal cells, not dermal fibroblasts, primarily contribute to dermal collagen formation. Fibroblasts play a role in modifying the collagen fibers already built by keratinocytes. We confirmed that collagen production by keratinocytes is a widely conserved mechanism in other model organisms. Our findings demand the current consensus about dermal collagen formation to change and lead to innovations in cosmetology and skin medication.