Macromolecules and drug delivery to solid  tumors is strongly influenced by fluid flow through interstitium, and pressure-induced tissue deformations can have a role in this. Recently, it has been shown that temperature-induced tissue deformation can influence interstitial fluid velocity and pressure fields, too. In this paper, the effect of modulating-heat strategies to influence interstitial fluid transport in tissues is analyzed. The whole tumor tissue is modeled as a deformable porous material, where the solid phase is made up by extracellular matrix and cells, while the fluid phase is the interstitial fluid that moves through the solid matrix driven by fluid pressure gradient and vascular capillaries that are modelled as uniformly interspersed fluid point-source. Pulsating-heat generation is modeled with a time-variable cosine function starting from a direct current approach to solve voltage equation, for different pulsations. From the steady-state solution, a step-variation of vascular pressure included in the model equation as a mass source term via Starling equation is simulated. Dimensionless 1D radial equations are numerically solved with a finite element-scheme. Results are presented in terms of temperature, volumetric strain, pressure and velocity profiles under different conditions. It is shown that a modulating-heat procedure influences velocity fields, that might have a consequence in terms of mass transport for macromolecules or drug delivery.

These data have been generated from numerical simulations on a mathematical model for interstitial flow through tumor tissues by considering thermal and mechanical effects too.

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