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Dryad

HIV-1 Subtypes of HIV-1 patients with virologic failure in different voluntary counseling testing and treatment centers in Khartoum State, Sudan, 2020

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Jan 03, 2023 version files 5.59 KB
Jan 16, 2023 version files 5.56 KB

Abstract

Background: Various HIV subtypes have evolved and play significant roles in the pathogenesis, progression, and response to treating human immunodeficiency virus.

Method: One hundred and ten HIV-1 patients who attended different voluntary counseling testing and treatment centers in Khartoum state were included. Nested PCR was done for the Pol gene in plasma samples that showed virologic failure, and then successfully amplified samples were sequenced for HIV-1 ­­subtype’s identification.

Result: Out of the total, 20 (18.2%) samples showed virologic failure, of them only 9 (45%) were successfully amplified and sequenced; of them, 55.6% (5/9) belonged to subtype C, and only 11.1% (1/9) occurred at the frequency of each subtype A, D, G, and K.

Conclusion: No relationship between HIV-1 subtypes and increased viral load were detected, although HIV-1 subtypes are still a strong predictor of disease progression.