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Data from: Simultaneous determination of diosmin and hesperidin in combined pharmaceutical preparation by synchronous fluorescence spectrofluorimetric method

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Mar 21, 2024 version files 32.03 KB

Abstract

Diosmin (DSM) and hesperidin (HSP) binary mixture was analyzed simultaneously by developing a sensitive, rapid, and simple synchronous spectrofluorimetric method. In methanol at ∆λ of 100 nm, the relative synchronous fluorescence intensities (RSFI) of both medications were measured. It was shown that these intensities were influenced by distinct experimental factors. The optimization and detailed study of these parameters were conducted. For DSM and HSP, respectively, the plots of synchronous fluorescence intensity-concentration were found to be rectilinear across the ranges of 0.5-5.0 µg/mL and 0.2-3.0 µg/mL. For DSM and HSP, respectively, 0.107 µg/mL and 0.048 µg/mL were the detection limits and 0.323 and 0.144 µg/mL were the limits of quantification. The method described in this study was effectively employed to estimate the quantities of both drugs present in commercially available mixed tablets. The results produced using this method were then compared favorably to results obtained using a different method for comparison.