Data from: Maternal nutrition during pregnancy affects testicular and bone development, glucose metabolism and response to overnutrition in weaned horses up to two years
Mendoza, Luis, University of Liège
Peugnet, Pauline, University of Paris-Saclay
Camous, Sylvaine, University of Paris-Saclay
Tarrade, Anne, University of Paris-Saclay
Robles, Morgane, University of Paris-Saclay
Serteyn, Didier, University of Liège
Caudron, Isabelle, University of Liège
Lejeune, Jean-Philippe, University of Liège
Dahirel, Michèle, University of Paris-Saclay
Chavatte-Palmer, Pascale, University of Paris-Saclay
Published Dec 19, 2017 on Dryad.
Cite this dataset
Gautier, Camille et al. (2017). Data from: Maternal nutrition during pregnancy affects testicular and bone development, glucose metabolism and response to overnutrition in weaned horses up to two years [Dataset]. Dryad. https://doi.org/10.5061/dryad.76dn2
Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of concentrates is linked to alterations of metabolism and the development of osteochondrosis in foals. The aim of this study was to determine if broodmare diet during gestation affects metabolism, osteoarticular status and growth of yearlings overfed from 20 to 24 months of age and/or sexual maturity in prepubertal colts. Twenty-four saddlebred mares were fed forage only (n=12, group F) or cracked barley and forage (n=12, group B) from mid-gestation until foaling. Colts were gelded at 12 months of age. Between 20 and 24 months of age, all yearlings were overfed (+140% of requirements) using an automatic concentrate feeder. Offspring were monitored for growth between 6 and 24 months of age, glucose homeostasis was evaluated via modified frequently sampled intra veinous glucose tolerance test (FSIGT) at 19 and 24 months of age and osteoarticular status was investigated using radiographic examinations at 24 months of age. The structure and function of testicles from prepubertal colts were analyzed using stereology and RT-qPCR. Post-weaning weight growth was not different between groups. Testicular maturation was delayed in F colts compared to B colts at 12 months of age. From 19 months of age, the cannon bone was wider in B vs F yearlings. F yearlings were more insulin resistant at 19 months compared to B yearlings but B yearlings were affected more severely by overnutrition with reduced insulin sensitivity. The osteoarticular status at 24 months of age was not different between groups. In conclusion, nutritional management of the pregnant broodmare and the growing foal may affect sexual maturity of colts and the metabolism of foals until 24 months of age. These effects may be deleterious for reproductive and sportive performances in older horses.
Nutrition of yearlings born to dams fed with forage only or forage and cereals in late gestation during feeding challenge
Horse feed unit (HFU, net energy, 1 HFU=2250kcal), horse digestible crude proteins (HDCP, g), crude fibers (g), calcium (g), phosphorus (g), digestible energy (DE, Mcal) and crude proteins (g) for each yearling between 576 and 738 days of age.
Growth of foals and yearlings born to dams fed with forage only or forage and cereals in late gestation
Body weight (kg), withers height (cm), cannon bone width (cm) and body condition score between 6 and 24 months of age.
Metabolism of yearlings born to dams fed with forage only or with forage and cereals in late gestation
Acute insulin response (AIRg, mU.min.L-1), insulin sensitivity (IS, x10-4 L.mU-1.min-1), disposition index (DI, x10-2), glucose effectiveness (Sg, x10-2.min-1), basal glucose (GB, mg.dL-1), basal insulin (IB, mU.L-1) and GB/IB ratio (mg.mU-1.daL) at 19 and 24 months of age.
Testicular maturation of prepubescent colts born to dams fed with forage only or with forage and cereals in late gestation
Lumen score (LS, 1 to 4) and gene expression (AR, AMH, Cx43, Cyp19, Occludin, Bcatenin, Ncadherin, Tjp1, P450c17, 3Bhsd and STAR) at 12 months of age