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Neural ensemble reactivation in REM and SWS coordinate with muscle activity to promote rapid motor skill learning

Citation

Eckert, Michael; McNaughton, Bruce; Tatsuno, Masami (2020), Neural ensemble reactivation in REM and SWS coordinate with muscle activity to promote rapid motor skill learning, Dryad, Dataset, https://doi.org/10.5061/dryad.7d7wm37rn

Abstract

Neural activity patterns of recent experiences are reactivated during sleep in structures critical for memory storage, including hippocampus and neocortex. This reactivation process is thought to aid memory consolidation. Although synaptic rearrangement dynamics following learning involve an interplay between slow-wave sleep (SWS) and rapid eye movement sleep (REM), most physiological evidence implicates SWS directly following experience as a preferred window for reactivation. Here we show that reactivation occurs in both REM and SWS, and that coordination of REM and SWS activation on the same day is associated with rapid learning of a motor skill. We performed 6-hour recordings from cells in rats’ motor cortex as they were trained daily on a skilled reaching task. In addition to SWS following training, reactivation occurred in REM, primarily during the pre-task rest period, and REM and SWS reactivation occurred on the same day in rats that acquired the skill rapidly. Both pre-task REM and posttask SWS activation were coordinated with muscle activity during sleep, suggesting a functional role for reactivation in skill learning. Our results provide the first demonstration that reactivation in REM sleep occurs during motor skill learning, and that coordinated reactivation in both sleep states on the same day, although at different times, is beneficial for skill learning.

Methods

Tetrode recordings from rat primary motor cortex during learning of skilled reaching task.  Recordings include sleep before and after daily training sessions.  The main analysis done was PCA reactivation based on Peyrache et al. 2009.

Funding

Defense Advanced Research Projects Agency, Award: HR0011-18-2-0021

Canadian Institutes of Health Research, Award: PJT 156040

National Science Foundation, Award: 1631465

Natural Sciences and Engineering Research Council of Canada, Award: 06109