Data from: Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal
Data files
Feb 15, 2018 version files 95.73 MB
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MC-sample1-HDL-AM.out
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MC-sample1-LDL-AM.out
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MC-sample1-TCHOL-AM.out
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MC-sample1-TG-AM.out
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MC-sample2-HDL-AM.out
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MC-sample2-LDL-AM.out
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MC-sample2-TCHOL-AM.out
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MC-sample2-TG-AM.out
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Mexico-City-AM-signals.xlsx
Abstract
We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.