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Association between seven-day serum β-hCG levels after frozen–thawed embryo transfer and pregnancy outcomes: a single-centre retrospective study from China

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Aug 18, 2020 version files 79.05 KB

Abstract

Objective: Early monitoring of plasma human chorionic gonadotropin (β-hCG) level is vital in predicting pregnancy outcome. This study investigated the predictive value of serum β-hCG level on the 7th day after frozen-thawed embryo transfer (FET) for ongoing pregnancy (OP) and adverse pregnancy (AP).

Design: Retrospective study

Setting: The Reproductive and Genetic Center of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China.

Participants: 1,061 pregnant women who underwent FET between January 2014 and January 2017.  

Primary and secondary outcome measures: Pregnancy outcome.

Results: Serum β-hCG levels on the 7th day after FET were higher in the single OP group compared to the biochemical pregnancy (BP) group (p 0.001). Besides, the serum β-hCG cutoff level at 4.34 mIU/mL on the 7th day showed high predictive value (area under the curve [AUC] = 0.852). Serum β-hCG levels on the 7th day after FET were higher in the twin OP group compared to the single OP group (p0.001). Also, the serum β-hCG cutoff level at 17.95 mIU/mL on the 7th day showed high predictive value (AUC = 0.903). Serum β-hCG levels on the 7th day after FET were lower in the ectopic pregnancy (EP) group compared to the single OP group (p 0.001) whereas, serum β-hCG cutoff level at 4.53 mIU/mL on the 7th day exhibited a high predictive value (AUC = 0.860). Further, the serum β-hCG levels on the 7th day after FET were lower in the single early spontaneous abortion (SA) group compared to the single OP group (p0.001) while the serum β-hCG cutoff level at 5.34 mIU/mL on the 7th day exhibited high predictive value (AUC = 0.738).

Conclusion: Serum β-hCG on the 7th day after FET has good clinical significance for the prediction of OP and AP.