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Data from: A lateral flow strip based on gold nanoparticles to detect 6-monoacetylmorphine in oral fluid

Citation

Liu, Jia et al. (2018), Data from: A lateral flow strip based on gold nanoparticles to detect 6-monoacetylmorphine in oral fluid, Dryad, Dataset, https://doi.org/10.5061/dryad.8r36rp3

Abstract

We used lateral flow strips (LFS) based on gold nanoparticles (AuNPs) to detect 6-monoacetylmorphine (6-MAM; heroin’s unique metabolite) in oral fluid samples. In this competitive lateral chromatographic immunoassay, the 6-MAM was chemically synthesized and conjugated to bovine serum albumin (BSA). The results were qualitatively detected via the color change of the test line. By using a proper sample pad, a suitable NC membrane and a customized sponge device adsorbed the oral fluid directly from mouth, and total test time was 3 minutes. The sensitivity of the assay was 4.0 ng ml-1 without any cross-reactivity with ten normal drugs, which are widely subject to abuse, including morphine and codeine. This test could be easily used on site to detect heroin in oral fluid, and it could be a promising product in the future including for driving under the influence.

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