Skip to main content
Dryad logo

A gene variation at the ZPR1 locus (rs964184) interacts with the type of diet to modulate postprandial triglycerides in patients with coronary artery disease: From the Cordioprev Study

Citation

Alcala-Diaz, Juan Francisco et al. (2022), A gene variation at the ZPR1 locus (rs964184) interacts with the type of diet to modulate postprandial triglycerides in patients with coronary artery disease: From the Cordioprev Study, Dryad, Dataset, https://doi.org/10.5061/dryad.9cnp5hqmh

Abstract

Background and Aims: rs964184 variant in the ZPR1 gene has been associated with blood lipids levels both in fasting and postprandial state and with the risk of myocardial
infarction in high-risk cardiovascular patients. However, whether this association is modulated by diet has not been studied.

Objective: To investigate whether the type of diet (low-fat or Mediterranean diets) interacts with genetic variability at this loci to modulate fasting and postprandial lipids in
coronary patients.

Materials and Methods: The genotype of the rs964184 polymorphism was determined in the Cordioprev Study population (NCT00924937). Fasting and Postprandial triglycerides were assessed before and after 3 years of dietary intervention with either a Mediterranean or a low-fat diet. Postprandial lipid assessment was done by a 4-h oral fat tolerance test (OFTT). Differences in triglycerides levels were identified using repeated-measures ANCOVA.

Results: From 523 patients (85% males, mean age 59 years) that completed the OFTT at baseline and after 3 years of intervention and had complete genotype information, 125
of them were carriers of the risk allele G. At the start of the study, these patients showed a higher fasting and postprandial triglycerides (TG) plasma levels. After 3 years of dietary
intervention, G-carriers following a Mediterranean Diet maintained higher fasting and postprandial triglycerides, while those on the low-fat diet reduced their postprandial
triglycerides to similar values to the population without the G-allele.

Conclusion: After 3 years of dietary intervention, the altered postprandial triglyceride response induced by genetic variability in the rs964184 polymorphism of the ZPR1 gene
can be modulated by a low-fat diet, better than by a Mediterranean diet, in patients with coronary artery disease.

Funding

Fundacion Patrimonio Comunal Olivarero

CEAS (Centro de Excelencia en Investigacion sobre Aceite de Oliva)

Junta de Andalucia (Consejeria de Salud, Consejeria de Agricultura y Pesca, Consejeria de Innovacion, Ciencia y Empresa)

Diputaciones de Jaen y Córdoba

Ministerio de Medio Ambiente, Medio Rural y Marino, Spanish Government

Ministerio de Ciencia e Innovacion, Spanish Goverment

Ministerio de Economia y Competitividad, Spanish Goverment

Consejeria de Salud, Junta de Andalucia