Input files of various genomic analyses used to unravel the domestication history of Cannabis
Cite this dataset
Ren, Guangpeng; Fumagalli, Luca (2021). Input files of various genomic analyses used to unravel the domestication history of Cannabis [Dataset]. Dryad. https://doi.org/10.5061/dryad.9p8cz8wfr
Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that C. sativa was first domesticated in early Neolithic times in East Asia and that all current hemp and drug cultivars diverged from an ancestral gene pool currently represented by feral plants and landraces in China. We identified candidate genes associated with traits differentiating hemp and drug cultivars, including branching pattern and cellulose/ lignin biosynthesis. We also found evidence for loss of function of genes involved in the synthesis of the two major biochemically competing cannabinoids during selection for increased fiber production or psychoactive properties. Our results provide a unique global view of the domestication of C. sativa and offer valuable genomic resources for ongoing functional and molecular breeding research.
Swiss National Science Foundation, Award: 31003A_130234
National Natural Science Foundation of China, Award: 31971391
Strategic Priority Research Program of Chinese Academy of Sciences, Award: XDB31010300
Second Tibetan Plateau Scientific Expedition and Research (STEP) Program, Award: 2019QZKK0502