Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation

Parapanov, Roumen, University Hospital of Lausanne, https://orcid.org/0000-0001-8101-7813

Hasenauer, Arpad, University Hospital of Lausanne

Bedat, Benoit, University Hospital of Lausanne

Lugrin, Jérôme, University Hospital of Lausanne

Debonneville, Anne, University Hospital of Lausanne

Abdelnour, Etienne, University Hospital of Lausanne

Gonzalez, Michel, University Hospital of Lausanne

Perentes, Jean, University Hospital of Lausanne

Piquilloud, Lise, University Hospital of Lausanne

Szabo, Csaba, University of Fribourg

Krueger, Thorsten, University Hospital of Lausanne

Liaudet, Lucas, University Hospital of Lausanne, https://orcid.org/0000-0003-2670-4930

roumen-nikolov.parapanov@chuv.ch, arpad.hasenauer@chuv.ch, benoit.bedat@chuv.ch, jerome.lugrin@chuv.ch, anne.debonneville@chuv.ch, etienne.abdelnour@chuv.ch, michel.gonzalez@chuv.ch, jean.perentes@chuv.ch, lise.piquilloud@chuv.ch, csaba.szabo@unifr.ch, thorsten.krueger@chuv.ch, lucas.liaudet@chuv.ch

Published Jan 07, 2022 on Dryad. https://doi.org/10.5061/dryad.9s4mw6mj3

Cite this dataset

Parapanov, Roumen et al. (2022). Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation [Dataset]. Dryad. https://doi.org/10.5061/dryad.9s4mw6mj3

Abstract

Lung transplantation (LTx) is associated with sterile inflammation, possibly related to the release of damage associated molecular patterns (DAMPs) by injured allograft cells. We have measured cellular damage and the release of DAMPs and cytokines in an experimental model of LTx after cold or warm ischemia and examined the effect of pretreatment with ex-vivo lung perfusion (EVLP).

Funding

Swiss National Fund for Scientific Research, Award: 310030_172975*

Swiss National Fund for Scientific Research, Award: 310030_188525*