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Data from: Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal

Citation

Jeong, Choongwon et al. (2019), Data from: Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal, Dryad, Dataset, https://doi.org/10.5061/dryad.bp46m

Abstract

Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting selective sweeps and polygenic adaptations and for mapping the genetic bases of physiological and fertility phenotypes in approximately 1000 indigenous ethnically Tibetan women from Nepal, adapted to high altitude. We performed genome-wide association analysis and tests for polygenic adaptations which showed evidence of positive selection for alleles associated with more pregnancies and live births and evidence of negative selection for those associated with higher offspring mortality. Lower hemoglobin level did not show clear evidence for polygenic adaptation, despite its strong association with an EPAS1 haplotype carrying selective sweep signals.

Usage Notes

Funding

National Science Foundation, Award: 1153911

Location

Tibetan Plateau
Himalayas
High Altitude
Nepal