1. Large carnivores of the genus Panthera can pose serious threats to public safety. Although the annual number of attacks on humans is rare compared to livestock depredation, such incidents undermine popular support for wildlife conservation and require immediate responses to protect human life. 2. We used a space-time scan method to perform a novel spatiotemporal analysis of 908 attacks on humans by lions, leopards and tigers to estimate the risks of further attacks in the same locales. 3. We found that a substantial proportion of attacks were clustered in time and space, but the dimension of these outbreaks varied between species. Lion outbreaks included more human fatalities, persisted for longer periods of time, and extended over larger areas than tiger or leopard outbreaks. 4. These techniques could be used by relevant agencies to warn local people of risks from further attacks within a certain time and distance following an initial incident by each species, as well as identify areas that require management interventions to address these threats.31-Oct-2018