Data from: Indirect protection from vaccinating children against influenza in households
Tsang, Tim K. et al. (2019), Data from: Indirect protection from vaccinating children against influenza in households, Dryad, Dataset, https://doi.org/10.5061/dryad.cj62621
Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized control trial, with one child in each household randomized to receive vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy is 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members is only reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.