Data from: Indirect protection from vaccinating children against influenza in households
Data files
Jan 10, 2019 version files 1.92 MB
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data_long.csv
123.74 KB
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data_round.csv
175.51 KB
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data.csv
81.67 KB
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Figure_2.R
1.65 KB
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Figure_3.R
2.90 KB
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Figure_4.R
2.95 KB
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Figure_5.R
14.35 KB
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ILILAB.csv
24.40 KB
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indirect_benefit_main.R
4.94 KB
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indirect_benefit_prediction.cpp
61.72 KB
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indirect_benefit.cpp
53.34 KB
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mcmc_result.csv
1.35 MB
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prediction_generator.R
1.19 KB
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prediction.R
5.27 KB
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README.txt
4.41 KB
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sub_inf.csv
42 B
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Table_S1.R
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Table_S2_3_4.R
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Table_S6.R
1.65 KB
Abstract
Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized control trial, with one child in each household randomized to receive vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy is 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members is only reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.