Data from: Indirect protection from vaccinating children against influenza in households
Data files
Jan 10, 2019 version files 1.92 MB
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data_long.csv
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data_round.csv
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data.csv
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Figure_2.R
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Figure_3.R
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Figure_4.R
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Figure_5.R
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ILILAB.csv
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indirect_benefit_main.R
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indirect_benefit_prediction.cpp
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indirect_benefit.cpp
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mcmc_result.csv
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prediction_generator.R
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prediction.R
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README.txt
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sub_inf.csv
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Table_S1.R
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Table_S2_3_4.R
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Table_S6.R
Abstract
Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized control trial, with one child in each household randomized to receive vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy is 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members is only reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.