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β-Elemene derivatives produced from SeO2-mediated oxidation reaction

Citation

He, Xingrui et al. (2020), β-Elemene derivatives produced from SeO2-mediated oxidation reaction, Dryad, Dataset, https://doi.org/10.5061/dryad.cnp5hqc1w

Abstract

We report herein the first access of ß-elemene derivatives through the SeO2-mediated oxidation reaction. Several new compounds were isolated through such one-step reaction, and their structures were elucidated using various 2D-NMR techniques. This method provides easy access to multiple oxidative ß-elemene derivatives in one single step, and represents the first cyclohexyl ring modifications of ß-elemene. It’s expected to open up the opportunity for future derivatization on cyclohexyl ring of ß-elemene. The new compounds obtained above showed better anti-proliferation activities on several cancer cell lines than ß-elemene itself.

Methods

The 1H NMR, 13C NMR, 1H-1H COSY, 1H-1H NOESY, HMBC, HSQC are recorded in 500 MHz NMR machine. The data were processed in MestReNova software.

Usage Notes

There is no any special instruction to obtain the data. Anyone in this field knows how to record NMR experience and how to interpret data.

Funding

Key projects of National Natural Science Foundation of China, Award: 81730108

Hangzhou Normal University startup fund, Award: 4125C5021920419

The Natural Science Foundation of Shandong Province, Award: ZR2019BB046