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The relationship between umbilical–portal–systemic venous shunt and outcome in 11 fetuses

Citation

Liu, Fang et al. (2021), The relationship between umbilical–portal–systemic venous shunt and outcome in 11 fetuses, Dryad, Dataset, https://doi.org/10.5061/dryad.crjdfn34g

Abstract

Objective: To investigate the relationship between congenital umbilical–portal–systemic venous shunt (UPSVs) and fetal outcome.

Methods: The ultrasonographic and genetic characteristics of 11 cases of UPSVS were retrospectively analyzed and followed up to postnatal.

Results: Four cases of ductus venosus -- systemic shunt (DVSS), one case of extrahepatic portal -- systemic shunt (EHPSS), and one case of umbilical systemic shunt (USS) combined with intrahepatic portal-systemic shunt (IHPSS), six cases of intrahepatic portal-systemic shunt (IHPSS) were observed. chromosomal abnormalities were observed in 9.1% (1/11), other ultrasonic abnormalities in 54.5% (6/11), cardiothoracic ratio increase in 45.5% (5/11), fetal growth restriction in 36.4% (4/11), edema was in 9.1% (1/11) and live birth was in 72.7% (8/11).

Conclusion: The incidence of IHPSS is the highest and the outcome is the best. Shunt of DVSS and IHPSS can be closed spontaneously after birth. When the prenatal diagnosis is congenital UPSVs, chromosomal abnormalities and other ultrasonic abnormalities should be required further examination, and the growth and development of the fetus should be closely monitored.

Methods

Retrospective analysis was performed on 11 cases of UPSVSs admitted to the prenatal diagnosis center of our hospital l from December 1, 2019, to December 1, 2020. According to the UPSVS classification criteria, four cases were DVSS, and six cases were IHPSS, including one case of USS combined with IHPSS and one case of EHPSS. All patients signed an informed consent form, performed routine ultrasound examinations of the fetus, placenta and amniotic fluid, and then performed detailed examinations and records of each fetus’s heart, celiac vessel and middle cerebral artery, focusing on observation of the umbilical vein and ductus venosus , main portal vein, left and right branch morphology, internal echo and surrounding structures, observed whether there are abnormal ducts between the umbilical vein, ductus venosus, portal vein, hepatic vein and other systemic veins, and follow up until the shunt is closed after birth. The karyotype and low-coverage massively parallel copy number variation sequencing (CNV-seq) of the fetus were further examined by amniocentesis. Statistical methods: Descriptive statistics were used to retrospectively analyze the clinical features and pregnancy outcomes of 11 cases. SPSS20.0 software was used for statistical analysis of data. Measurement data was expressed as mean(±SD), and the Bonferroni adjustment method in ANOVA was used for pairwise comparison. p<0.05 indicates that the difference is statistically significant. Counting data are expressed as percentages.