Molecular dynamics simulations of the tripartite interface (Syt1_C2B—SNARE—Cpx Complex)
Cite this dataset
Brunger, Axel; Leitz, Jeremy (2022). Molecular dynamics simulations of the tripartite interface (Syt1_C2B—SNARE—Cpx Complex) [Dataset]. Dryad. https://doi.org/10.5061/dryad.f1vhhmh15
Abstract
Synaptic transmission is mediated by an orchestra of presynaptic proteins that precisely control and trigger fusion between synaptic vesicles and the neuron terminal at the active zone upon an action potential. Critical to this process are the neuronal SNAREs (Soluble N-ethylmaleimide sensitive factor Attachment protein REceptor), the Ca2+-sensor synaptotagmin, the activator/regulator complexin, and other factors. Here we present the data for molecular dynamics simulations of the tripartite interface bewteen these proteins.
Methods
See README.md file.
Usage notes
See README.md file.
Funding
Howard Hughes Medical Institute
National Institute of Mental Health, Award: R01MH063105