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Molecular dynamics simulations of the tripartite interface (Syt1_C2B—SNARE—Cpx Complex)

Citation

Brunger, Axel; Leitz, Jeremy (2022), Molecular dynamics simulations of the tripartite interface (Syt1_C2B—SNARE—Cpx Complex), Dryad, Dataset, https://doi.org/10.5061/dryad.f1vhhmh15

Abstract

Synaptic transmission is mediated by an orchestra of presynaptic proteins that precisely control and trigger fusion between synaptic vesicles and the neuron terminal at the active zone upon an action potential. Critical to this process are the neuronal SNAREs (Soluble N-ethylmaleimide sensitive factor Attachment protein REceptor), the Ca2+-sensor synaptotagmin, the activator/regulator complexin, and other factors. Here we present the data for molecular dynamics simulations of the tripartite interface bewteen these proteins. 

Methods

See README.md file.

Usage Notes

See README.md file.

Funding

Howard Hughes Medical Institute

National Institutes of Health, Award: R01MH063105