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Dryad

Experimental peritoneal dialysis in Sprague-Dawley rats using conventional or low sodium dialysis fluids

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Feb 16, 2024 version files 29.63 KB

Abstract

During peritoneal dialysis, sodium is transferred in a paracellular fashion via inter-endothelial nanochannels from the blood plasma water to the dialysate and, initially, dialysate sodium concentrations are also diluted by free water transport across endothelial aquaporin-1 channels. These experiments were performed to evaluate the relative contributions of free water transport, convective- and diffusive transfer on dialysate sodium. Based on our findings, we devised a simple method to quantify ultrafiltration by analyzing the initial decline in dialysate sodium concentration, commonly referred to as the "sodium dip."