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Data from: Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: a multicenter case-control study

Citation

Kazemi, Maryam et al. (2020), Data from: Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: a multicenter case-control study, Dryad, Dataset, https://doi.org/10.5061/dryad.gxd2547h9

Abstract

Context: Osteosarcopenia (loss of skeletal muscle and bone mass and/or function usually associated with aging) shares pathophysiological mechanisms with polycystic ovary syndrome (PCOS). However, the relationship between osteosarcopenia and PCOS remains unclear.

Objective: We evaluated skeletal muscle index% (SMI%=[appendicular muscle mass/weight {kg}]×100) and bone mineral density (BMD) in PCOS (hyperandrogenism+oligoamenorrhea), and contrasted these musculoskeletal markers against 3 reproductive phenotypes: (1) HA (hyperandrogenism+eumenorrhea); (2) OA (normoandrogenic+oligoamenorrhea) and, (3) controls (normoandrogenic+eumenorrhea). Endocrine predictors of SMI% and BMD were evaluated across groups.

Design, Setting, Participants: Multicenter case-control study of 203 women (18–48y) in New York State. 

Results: PCOS group exhibited reduced SMI% (mean [95%CI]; 26.2% [25.1,27.3] vs. 28.8% [27.7,29.8]), lower-extremity SMI% (57.6% [56.7,60.0] vs. 62.5% [60.3,64.6]), and BMD (1.11 [1.08,1.14] vs. 1.17 [1.14,1.20] g/cm2) compared to controls. PCOS group also had decreased upper (0.72 [0.70,0.74] vs. 0.73 [0.71,0.76] g/cm2) and lower (1.13 [1.10,1.16] vs. 1.15 [1.12,1.18] g/cm2) limb BMD compared to HA. Matsuda index was lower in PCOS vs. controls and positively associated with SMI% in all groups (All:P≤0.05). Only controls showed associations between insulin-like-growth-factor-1 (IGF-1) and upper (r=0.84) and lower (r=0.72) limb BMD (All:P<0.01). Unlike in PCOS, IGF binding-protein-2 was associated with SMI% in controls (r=0.45) and HA (r=0.67), and with upper limb BMD (r=0.98) in HA (All:P<0.05).

Conclusions: Women with PCOS exhibit early signs of osteosarcopenia compared to controls likely attributed to disrupted insulin function. Understanding the degree of musculoskeletal deterioration in PCOS is critical for implementing targeted interventions that prevent and delay osteosarcopenia in this clinical population.

Funding

Division of Nutritional Sciences at Cornell University

National Institutes of Health, Award: R56-HD089962

National Institutes of Health, Award: ULTR000457

United States Department of Agriculture, Award: 61329

President’s Council of Cornell Women, and the Academy of Nutrition and Dietetics Foundation

National Institutes of Health, Award: T32-DK007158

Division of Nutritional Sciences at Cornell University