Evaluation of assisted reproductive technology treatment outcomes based on stimulation dosages and anti-mullerian hormone levels
Pannu, Navdeep (2022), Evaluation of assisted reproductive technology treatment outcomes based on stimulation dosages and anti-mullerian hormone levels, Dryad, Dataset, https://doi.org/10.5061/dryad.gxd2547pr
Background: Serum concentrations of anti-mullerian hormone (AMH) correlate with ovarian response during assisted reproductive (ART) treatment cycles. This prospective study was attempted to evaluate the selection of ovarian stimulation protocols based on serum AMH levels in patients and its impact on the results of ART.
According to the AMH levels, majority of the patients were normal responders (52.4%) followed by high responders (29.8%) and low responders (17.8%). The average FSH, HMG per day and number of days HMG required was found to be significant among the different responders. Further, retrieval rate and blastulation rate was found to be significant among the different responders. A positive correlation was found between AMH and number of oocytes retrieved and number of oocytes successfully fertilized and it was found to be significant. In addition, there was a significant inverse relationship between AMH levels and age.
The study outcome reveals that retrieval rate, maturation rate, fertilization rate, embryo utilization rate and blasturation rate were higher among the high responders as compared to low responders. Thus, proper increase in dosages of ovarian stimulation protocol is required among the low responders to achieve quality embryos.
Based on the serum AMH, 191 women were classified as low, normal and high responders. Follicle Stimulating Hormone (FSH) and Human Menopausal Gonadotropin (HMG) dosages in controlled ovarian stimulation were determined. Retrieval, maturation, fertilization and utilization rates were measured. Subgroup analysis was done using One way ANOVA followed by post hoc analysis. The relationship between AMH levels and fertilization was done using Pearson’s correlation analysis. A p value <0.05 was considered as statistically significant.