Objective: Diffuse low-grade gliomas (DLGG) are defined by a continuous growth and an almost unavoidable malignant transformation. Foci of malignant glioma can be found within DLGG samples obtained from surgical resections. As the medical management of patients is classically based on the higher tumor grade, an immediate adjuvant treatment is usually proposed. To determine whether postponing the medical treatment in selected patients is feasible, we conducted a single-center retrospective study. Methods: Single-center retrospective analysis of a consecutive series of DLGG managed with this conservative strategy. Inclusion criteria were: at least one focus of malignant tumor (grade III-IV, WHO 2016), no previous chemotherapy or radiotherapy, no less than a subtotal resection of the FLAIR tumor volume, no intention of treating with immediate adjuvant therapy, minimum two years of follow-up. The time interval to the following oncological medical treatment was analyzed, as well as the functional and survival results. Results: 45 patients met the inclusion criteria (median age 36.5, median time interval from diagnosis: 7.3 months). Most tumors (86.7%) were IDH-mutant and 1p19q intact (60.0%); 10 presented with grade IV foci. With a median follow-up of 6.3 years, 75.5% of patients received a subsequent medical treatment, after a median time of 3.7 years since surgery. At the time of analysis, 9 patients (20.0%) had died (5-years and 7-years survival rates: 95.2% and 67.0%). Most surviving patients were still active professionally, without seizures. Conclusions: Postponing the medical treatment in DLGG with foci of malignant tumor following total or subtotal resection should be considered in selected patients.