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Dryad

Data from: Serosurvey of SARS-COV-2 at a large public university

Data files

Jul 12, 2023 version files 157.24 KB

Abstract

Objective: This study investigated the seroprevalence of SARS-CoV-2 antibodies among adults over 18 years.

Design: Prospective cohort study.

Settings: a population-based study among the big university community.

Participants: This study took volunteers over five days and recruited adult 1064 participants.

Primary outcome measures: We conducted a seroprevalence in our community with SARS-CoV-2-specific antibodies due to previous exposure to SARS-CoV-2 and/or vaccination.

Results: The seroprevalence of the anti-receptor binding domain (RBD) antibody was 90% by a lateral flow assay and 88% by a semi-quantitative chemiluminescent immunoassay. The seroprevalence for anti-nucleocapsid (NC) was 20%. In addition, individuals with previous natural COVID infection plus vaccination had higher anti-RBD antibody levels compared to those who had vaccination only or infection only. Individuals who had a breakthrough infection had the highest anti-RBD antibody levels.

Conclusion: Accurate estimates of the cumulative incidence of SARS-CoV-2 infection can inform the development of university risk mitigation protocols such as encouraging booster shots, extending mask mandates, or reverting to online classes. It could help us to have clear guidance to act at the first sign of the next surge as well, especially since there is a surge of COVID subvariant infections.