Deep understanding of lifelong tooth replacement is hampered by the lack of polyphyodonty or oral dentition in conventional models. Here, we show that the bearded dragon, one of the rare vertebrate species with both polyphyodont and monophyodont teeth, constitutes a key model for filling this gap, allowing direct comparison of extreme dentition types. Our developmental and high-throughput transcriptomic data of microdissected dental cells unveils the critical importance of successional dental lamina patterning, in addition to maintenance, for vertebrate tooth renewal. This patterning process happens at various levels, including directional growth but also gene expression levels, dynamics, and regionalization, and involves a large number of yet uncharacterized dental genes. Furthermore, the alternative renewal mechanism of bearded dragon dentition, with dual location of slow-cycling cells, demonstrates the importance of cell migration and functional specialization of putative epithelial stem/progenitor niches in tissue regeneration, while expanding the diversity of dental replacement strategies in vertebrates.
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 2
PVADME2.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 3
PVADME3.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 1
PVADME1.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of successional dental lamina tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 1
PVASDL1.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of successional dental lamina tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 2
PVASDL2.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of successional dental lamina tissues of acrodont teeth from Pogona vitticeps lizard, biological replicate 3
PVASDL3.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 1
PVPDME1.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 2
PVPDME2.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of dental mesenchyme tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 3
PVPDME3.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of successional dental lamina tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 1
PVPSDL1.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of successional dental lamina tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 2
PVPSDL2.tar.gz
Pogona vitticeps tooth transcriptomics
Paired-end sequencing reads (Illumina technology) of successional dental lamina tissues of pleurodont teeth from Pogona vitticeps lizard, biological replicate 3
PVPSDL3.tar.gz