Typhonium muaklekense sp. nov. was collected from the Muak Lek district, Saraburi province, Thailand. Morphologically, the spathe of this species resembles T. roxburghii Schott and T. varians Hett. & Sookch., but the leaves are distinctly different by orbicular leaf blades. Critical observation and analysis of the specimens indicated that they represent a previously unrecognized species that we are naming T. muaklekense based on its occurrence in the Muak Lek district, Saraburi province, Thailand. Typhonium muaklekense D. Sookchaloem & S. Maneeanakekul is described and illustrated. The new species resembles T. roxburghii Schott and T. varians Hett. & Sookch. in the spathe. Drawings, photographs and a table comparing diagnostic features of T. muaklekense, T. roxburghii and T. varians are provided.