This paper for the 20th anniversary of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) provides an overview of magnetic resonance imaging (MRI) of medial temporal lobe (MTL) subregions in ADNI using a dedicated high-resolution T2-weighted sequence. A review of the work that supported the inclusion of this imaging modality into ADNI Phase 3 is followed by a brief description of the ADNI MTL imaging and analysis protocols and a summary of studies that have used these data. This review is supplemented by a novel study that uses novel surface-based tools to characterize MTL neurodegeneration across biomarker-defined AD stages. This analysis reveals a pattern of spreading cortical thinning associated with increasing levels of tau pathology in presence of elevated beta-amyloid, with apparent epicenters in the transentorhinal region and inferior hippocampal subfields. The paper concludes with an outlook for high-resolution imaging of the MTL in ADNI Phase 4.

This dataset contains the template and model package for use with CRASHS. CRASHS is a surface analysis pipeline for medial temporal lobe anatomical structures. It uses output of the ASHS pipeline (automatic segmentation of hippocampal subfields) as input. The CRASHS template contains geometrical models and deep learning networks used internally by the CRASHS software to match an individual's temporal lobe to a template.

Please see CRASHS documentation for instructions on using the package.