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Data from: Temperature compensation in a small rhythmic circuit

Citation

Alonso, Leandro; Marder, Eve (2020), Data from: Temperature compensation in a small rhythmic circuit, Dryad, Dataset, https://doi.org/10.5061/dryad.m31b1h7

Abstract

Temperature affects the conductances and kinetics of the ionic channels that underlie neuronal activity. Each membrane conductance has a different characteristic temperature sensitivity, which raises the question of how neurons and neuronal circuits can operate robustly over wide temperature ranges. To address this, we employed computational models of the pyloric network of crabs and lobsters. We employed a landscape optimization scheme introduced previously (Alonso and Marder, 2019) to produce multiple different models that exhibit a triphasic pyloric rhythm over a range of temperatures. We use the currentscapes introduced in (Alonso and Marder, 2019) to explore the dynamics of model currents and how they change with temperature. We found that temperature changes the relative contributions of the currents to neuronal activity so that rhythmic activity smoothly slides through changes in mechanisms. Moreover, the responses of the models to extreme perturbations—such as gradually decreasing a current type—are often qualitatively different at different temperatures.

Usage Notes

Funding

National Institutes of Health, Award: T32 NS07292

Swartz Foundation, Award: Swartz Foundation 2017