Data from: Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

Wong, Sau May, Maastricht University Medical Centre

Jansen, Jacobus F. A., Maastricht University Medical Centre

Zhang, C. Eleana, Maastricht University Medical Centre

Hoff, Erik I., Department of Neurology, Zuyderland Medical Centre, Heerlen, the Netherlands.

Staals, Julie, Maastricht University Medical Centre

van Oostenbrugge, Robert J.

Backes, Walter H., Maastricht University Medical Centre

Published Mar 15, 2019 on Dryad. https://doi.org/10.5061/dryad.m9c8tn8

Cite this dataset

Wong, Sau May et al. (2019). Data from: Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease [Dataset]. Dryad. https://doi.org/10.5061/dryad.m9c8tn8

Abstract

Objective: To investigate the link between BBB permeability and CBF and the relation with white matter hyperintensities (WMHs) in cerebral small vessel disease (cSVD). Methods: Twenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively. Structural MR images were segmented into normal appearing white matter (NAWM) and WMHs, for which a perilesional zone was defined. In these regions, we investigated the BBB permeability, CBF, and their relation using Pearson correlation r. Results: We found a decrease in CBF of 2.2 mL/min/100g(p<0.01) and an increase in leakage volume of 0.7%(p<0.01) per mm closer to the WMHs in the perilesional zones. Lower CBF values correlated with higher leakage measures in the NAWM and WMHs (-0.53

Usage notes

e-Supplemental_ID_NEUROLOGY_2018_893248

e-Supplemental of manuscript titled: Blood-Brain Barrier Impairment and Hypoperfusion are linked in Cerebral Small Vessel Disease by Wong et al.