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Dryad

Processed FDG-PET data from: A computational model of neurodegeneration in Alzheimer’s disease

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Feb 14, 2022 version files 220.83 MB

Abstract

Disruption of mental functions in Alzheimer’s disease (AD) and related disorders is accompanied by selective degeneration of brain regions. These regions comprise large-scale ensembles of cells organized into systems for mental functioning, however the relationship between clinical symptoms of dementia, patterns of neurodegeneration, and functional systems is not clear.  We developed a model of the association between dementia symptoms and degenerative brain anatomy using F18-fluorodeoxyglucose (FDG) PET and dimensionality reduction techniques patients with AD. This data and code package contains preprocessed FDG-PET images from 423 subjects across the Alzheimer’s disease spectrum and the MATLAB code to produce eigenbrains from this data.