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Data from: Glutamate sensor and calcium signals in dopamine neurons and dopamine release

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Dec 21, 2023 version files 3.34 GB

Abstract

We recorded glutamate input to dopamine neurons in the ventral tegmental area (VTA) with iGluSnFR(A184S), a glutamate sensor, somatodendritic dopamine neuron activity in the VTA with jGCaMP7f, a calcium indicator, and dopamine release at the ventral striatum (VS) with GrabDA2m, a dopamine sensor, using fiber fluorometry. Recordings were performed in two types of reward association tasks (classical conditioning and sequential conditioning), with presentation of aversive airpuff to the eye with or without buprenorphine treatment, and with optogenetic activation of glutamate input axons at the VTA.