Mechanisms of individualized fMRI neuromodulation for visual perception and visual imagery
Data files
Dec 05, 2024 version files 60.05 GB
-
10_segmentation_CSF_mask.zip
9.84 KB
-
Data.zip
60.05 GB
-
README.md
2.86 MB
Abstract
Neuromodulation is a growing precision-medicine approach to modulating neural activity that can be used to treat neuropsychiatric, and general pathophysiologic conditions. We developed individualized fMRI neuromodulation (iNM) to study the mechanisms of visuospatial perception modulation with the long-term goal of applying it in low-vision patient populations having cortical blindness or visuospatial impairment preceding subjective cognitive impairment. To determine these mechanisms, we developed a direction and coherence discrimination task to engage visual perception (VP), visual imagery (VI), selective extero-intero-ceptive attention (SEIA), and motor planning (MP) networks. Participants discriminated up and down direction, at full and subthreshold coherence under iNM or control (no iNM). We determined the blood-oxygen-level-dependent (BOLD) magnitude as the area under the curve (AUC) for VI, SEIA, and MP encoded networks and used a decoder to predict the stimulus from brain maps.
README: Mechanisms of individualized fMRI neuromodulation for visual perception and visual imagery
https://doi.org/10.5061/dryad.ngf1vhj1m
The following figure depicts our Individualized real-time functional MRI closed-loop neuromodulation (iNM) Intervention.