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Data from: The early spread and epidemic ignition of HIV-1 in human populations

Citation

Faria, Nuno R. et al. (2015), Data from: The early spread and epidemic ignition of HIV-1 in human populations, Dryad, Dataset, https://doi.org/10.5061/dryad.nn952

Abstract

Thirty years after the discovery of HIV-1, the early transmission, dissemination and establishment of the virus in human populations remain unclear. Using statistical approaches applied to HIV-1 sequence data from central Africa, we show that from the 1920s Kinshasa was the focus of early transmission and the source of pre-1960 pandemic viruses elsewhere. Location and dating estimates were validated using the earliest HIV-1 archival sample, also from Kinshasa. The epidemic histories of HIV-1 group M and non-pandemic group O were similar until ~1960, after which group M underwent an epidemiological transition and outpaced regional population growth. Our results reconstruct the early dynamics of HIV-1 and emphasize the role of social changes and transport networks in the establishment of this virus in human populations.

Usage Notes

Location

Central Africa
Southern Africa and USA