Data from: Cross-sectional study of patients with axial spondyloarthritis fulfilling imaging arm of ASAS classification criteria: baseline clinical characteristics and subset differences in a single centre cohort
Bubova, Kristyna et al. (2019), Data from: Cross-sectional study of patients with axial spondyloarthritis fulfilling imaging arm of ASAS classification criteria: baseline clinical characteristics and subset differences in a single centre cohort, Dryad, Dataset, https://doi.org/10.5061/dryad.pb5316b
Objective: This study compared demographic, clinical and laboratory characteristics between patients with radiographic and non-radiographic axSpA. Methods: In this single centre cross-sectional study a total of 246 patients with axSpA fulfilling the imaging arm of ASAS classification criteria were recruited. A total of 140 patients were diagnosed as nr-axSpA, and 106 patients had AS. Sociodemographic characteristics, disease manifestations, clinical and laboratory disease activity and their differences between subsets were analysed. P values below 0.05 with CI 95% were considered statistically significant. Results: More nr-axSpA patients were females (61.4%) compared to 24.7% of AS patients. First symptoms developed earlier in AS patients compared to nr-axSpA (23.0 (IQR 17.5-30.0) vs. 27.8 (IQR 21.0-33.7) years, p=0.001). Disease manifestations did not differ, but patients with nr-axSpA experienced peripheral arthritis more frequently (35.7% vs. 17.0%, p=0.001) with less hip involvement (8.6% vs. 18.9%, p=0.022) compared to patients with AS. Patients with AS exhibited worse spinal mobility and physical function compared to nr-axSpA. Ankylosing Spondylitis Disease Activity Scores and CRP levels were significantly higher in patients with AS compared to nr-axSpA (2.4 (IQR 1.7-2.8) vs. 2.0 (IQR 1.1-2.3), p=0.022 and 7.1 (IQR 2.6-14.9) vs. 2.5 (IQR 0.8-8.2) mg/L, p<0.001, respectively). Conclusions: Our data demonstrated some known and also novel differences between the two imaging arm fulfilling axSpA subgroups. Non-radiographic patients were mostly women who had experienced shorter disease duration, milder disease activity and better functional status with less hip involvement but more peripheral arthritis compared to patients with AS.