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Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex

Citation

Zhang, Qingguang; Gheres, Kyle; Drew, Patrick (2021), Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex, Dryad, Dataset, https://doi.org/10.5061/dryad.pg4f4qrmt

Abstract

The concentration of oxygen in the brain spontaneously fluctuates, and the distribution of power in these fluctuations has a 1/f-like spectra, where the power present at low frequencies of the power spectrum is orders of magnitude higher than at higher frequencies. Though these oscillations have been interpreted as being driven by neural activity, the origins of these 1/f-like oscillations is not well understood. Here, to gain insight of the origin of the 1/f-like oxygen fluctuations, we investigated the dynamics of tissue oxygenation and neural activity in awake behaving mice. We found that oxygen signal recorded from the cortex of mice had 1/f-like spectra. However, band-limited power in the local field potential, did not show corresponding 1/f-like fluctuations. When local neural activity was suppressed, the 1/f-like fluctuations in oxygen concentration persisted. Two-photon measurements of erythrocyte spacing fluctuations and mathematical modelling show that stochastic fluctuations in erythrocyte flow could underlie 1/f-like dynamics in oxygenation. These results suggest that the discrete nature of erythrocytes and their irregular flow, rather than fluctuations in neural activity, could drive 1/f-like fluctuations in tissue oxygenation.

Usage Notes

INSTRUCTIONS FOR DOWNLOADING DATA
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The data are included in one zipped folder. Download and extract the .zip files titled: "Zhang_PLoS_Biology_2021.zip" 


INFORMATION ABOUT THE INCLUDED DATA
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Folder with the name "Ephys" contains all data collected using 16-channel laminar electrodes

Folder with the name "Oxygen" contains all the data collected using polarographic oxygen electrodes.

Folder with the name "Oxyen_Ephys_resp" contains all the data used as an example for Figure 5b

Folder with the name "Oxygen_prediction" contains all the data used for calculating HRF and predicting oxygenation.

Folder with the name "QZ0360_DV300" contains all the data used as an example for Figure 1bcd and Figure 2c.

Folder with the name "QZ0373_DV300" contains all the data used as an example for Figure 1bcd.

Folder with the name "RBC_results" contains all the data collected using 2PLSM, as well as the computational model.

File with the name "RestVar_drug_scatter.mat" contains all the LFP, oxygen and respiration data collected simultaneously.

Funding

National Institutes of Health, Award: R01NS078168

National Institutes of Health, Award: R01NS108407