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The effects of body mass on immune cell concentrations of terrestrial mammals

Citation

Downs, Cynthia J. et al. (2019), The effects of body mass on immune cell concentrations of terrestrial mammals, Dryad, Dataset, https://doi.org/10.5061/dryad.q4n4884

Abstract

Theory predicts that body mass should affect the way organisms evolve and use immune defenses. We investigated the relationship between body mass and blood neutrophil and lymphocyte concentrations among 250+ terrestrial mammalian species. We tested whether existing theories (e.g., Protecton Theory, immune system complexity, and rate of metabolism) accurately predicted the scaling of immune cell concentrations. We also evaluated the predictive power of body mass for these leukocyte concentrations compared to sociality, diet, life history, and phylogenetic relatedness. Phylogeny explained >65% of variation in both lymphocytes and neutrophils, and body mass appeared more informative than other interspecific trait variation. In the best-fit mass-only model, neutrophils scaled hypermetrically (b = 0.11) with body mass whereas lymphocytes scaled isometrically. Extrapolating to total cell numbers, this exponent means that an African elephant circulates 13.3 million times the neutrophils of a house mouse, whereas their masses differ by only 250k-fold. We hypothesize that such high neutrophil numbers might offset the i) higher overall parasite exposure that large animals face and/or ii) the higher relative replication capacities of pathogens to host cells.

Usage Notes

Funding

National Science Foundation, Award: IOS-0947177

National Science Foundation, Award: IOS-1257773

National Science Foundation, Award: IOS-1656618

National Science Foundation, Award: IOS-1656551