Data from: Gene expression, chromosome heterogeneity and the fast-X effect in mammals
Nguyen, Linh-Phuong; Galtier, Nicolas; Nabholz, Benoit; Nguyen, L.-P. (2015), Data from: Gene expression, chromosome heterogeneity and the fast-X effect in mammals, Dryad, Dataset, https://doi.org/10.5061/dryad.qr20n
The higher rate of non-synonymous over synonymous substitutions (dN/dS) of the X chromosome compared with autosomes is often interpreted as a consequence of X hemizygosity. However, other factors, such as gene expression, are also known to vary between X and autosomes. Analysing 4800 orthologues in six mammals, we found that gene expression levels, associated with GC content, fully account for the variation in dN/dS between X and autosomes with no detectable effect of hemizygosity. We also report an extensive variance in dN/dS and gene expression between autosomes.