Two green, sensitive and simple synchronous spectrofluorimetric methods were developed for the simultaneous estimation of febuxostat and ibuprofen for the first time. Method I is constant-wavelength synchronous spectrofluorimetry where febuxostat and ibuprofen were recorded at 329 and 258 nm, respectively using Δλ of 40 nm. Method II is constant-energy synchronous spectrofluorimetry using a wave-number interval of -4000 cm⁻¹. All measurements were performed in a borate buffer of pH 7 and distilled water for dilution which increased the method greenness. The two methods were rectilinear over the concentration ranges of 30.0-700.0 ng mL^-1 and 0.5-9.0 µg mL^-1 in method I and 20.0-500.0 ng mL^-1 and 0.1-8.0 µg mL^-1 in method II for febuxostat and ibuprofen, respectively. High sensitivity was attained for the two drugs with LODs down to 0.40 and 5.6 ng mL^-1 in method I and 0.25 and 3.4 ng mL^-1 in method II for febuxostat and ibuprofen, respectively. Recovery percentages were in the range of 97.3-101.9 % after extraction from spiked human plasma samples, demonstrating high bioanalytical applicability. The two methods were furtherly applied to tablet dosage forms with good recovery results. Furthermore, the method greenness was assessed according to the analytical Eco-Scale and Green Analytical Procedure Index guidelines.