Data from: Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: a case-control study
Can, Anil et al. (2019), Data from: Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: a case-control study, Dryad, Dataset, https://doi.org/10.5061/dryad.s6k4b4j
Objective: We aimed to determine the association between ruptured saccular aneurysms and aspirin use/aspirin dose. Methods: 4,701 patients who were diagnosed at the Massachusetts General Hospital and Brigham and Women’s Hospital between 1990 and 2016 with 6,411 unruptured and ruptured saccular intracranial aneurysms were evaluated. Univariable and multivariable logistic regression analyses were performed to determine the association between aSAH and aspirin use, including aspirin dose. Inverse probability weighting using propensity scores was used to adjust for potential differences in baseline characteristics between cases and controls. Additional analyses were performed to examine the association of aspirin use and re-rupture prior to treatment. Results: In multivariate analysis with propensity score weighting, aspirin use (OR 0.60, 95% CI 0.45-0.80) was significantly associated with decreased risk of ruptured intracranial aneurysms. There was a significant inverse dose-response relationship between aspirin dose and aneurysmal subarachnoid hemorrhage (OR 0.65, 95% CI 0.53-0.81). In contrast, there was a significant association between aspirin use and increased risk of re-rupture prior to treatment (OR 8.15, 95% CI 2.22-30.0). Conclusions: In this large case-control study, aspirin therapy at diagnosis was associated with a significantly decreased risk of subarachnoid hemorrhage, with an inverse dose-response relationship among aspirin users. However, once rupture has occurred, aspirin is associated with an increased risk of re-rupture prior to treatment.