Gender and age-related differences of ccular biometric parameters in patients undergoing cataract surgery in Bosnia and Herzegovina
Data files
Nov 03, 2023 version files 303.11 KB
Jan 02, 2024 version files 301.34 KB
Abstract
Purpose: To determine the distribution and mutual relationship of ocular biometric parameters, as well as to evaluate gender- and age-related differences in patients undergoing cataract surgery in Bosnia and Herzegovina.
Materials and methods: It was a retrospective cross-sectional study of consecutive patients who underwent cataract surgery between January 2017 and December 2021 in a tertiary care clinic. All biometric measurements were performed using the optical biometer OA-2000 (Tomey, Nagoya, Japan).
Results: The study evaluated 1278 eyes from 1278 consecutive cataract patients. The average age of all included patients was 69.4 ± 9.98 (range 40–96). A total of 672 eyes (52.58%) were from females. The mean axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and mean keratometry were 23.46±1.18mm, 3.17±0.40mm, 4.54±0.48mm, 43.42±1.55D respectively. Corneal astigmatism of ≥1D, >2D and >3D was found in 33.4%, 7.8% and 2.5% patients, respectively. Females were found to have shorter AL (p<0.0001), shallower ACD (p<0.0001) and steeper corneas (p<0.0001). In both genders, AL, ACD and with-the-rule astigmatism showed a decreasing trend (p=0.0001), while keratometry, the average cylinder, and against-the-rule astigmatism showed an increasing trend (p=0.0001) with increasing age. Furthermore, in both genders, there was an increasing trend in ACD (p=0.0001), and a decreasing trend in keratometry (p=0.0001) and LT (p=0.0001) with increasing AL.
Conclusions: This study provides useful reference data on ocular biometry for cataract surgeons in Bosnia and Herzegovina. Female patients tend to have steeper corneas, shorter AL and shallower AC than males, and these differences are independent of age or AL.
README
GENERAL INFORMATION
- Title of Dataset: GENDER AND AGE-RELATED DIFFERENCES OF OCULAR BIOMETRIC PARAMETERS IN PATIENTS UNDERGOING CATARACT SURGERY IN BOSNIA AND HERZEGOVINA
- Author Information
A. Principal Investigator Contact Information
Name: Edita Zvorničanin
Institution: Private Healthcare Institution Vase zdravlje, Tuzla, Bosnia and Herzegovina
Address: Ulica Ismeta Mujezinovića br 27, 75000 Tuzla, B&H
Email:
B. Associate or Co-investigator Contact Information
Name: Zoran Vatavuk
Institution: Department of Ophthalmology, University Clinical Centre "Sestre milosrdnice," Eye Clinic Cancer, Zagreb Croatia
Address: Vinogradska cesta 29, 10000 Zagreb
Email: zo.vatavuk@gmail.com
B. Associate or Co-investigator Contact Information
Name: Maja Popović
Institution: Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte
Address: Via Santena 7, Turin 10125, Italy
Email: maja.popovic@unito.it
B. Associate or Co-investigator Contact Information
Name: Jasmin Zvorničanin
Institution: Department of Ophthalmology, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
- Date of data collection: 1st January 2017 to 31st December 2021.
- Geographic location of data collection: Tuzla Canton, Bosnia and Herzegovina
- Information about funding sources that supported the collection of the data: No funding was received for this research. SHARING/ACCESS INFORMATION
- Licenses/restrictions placed on the data: NONE
- Links to publications that cite or use the data: In review
- Links to other publicly accessible locations of the data: NONE.
- Links/relationships to ancillary data sets: NONE.
- Was data derived from another source? NO.
- Recommended citation for this dataset: Zvorničanin, Edita; Vatavuk, Zoran; Popović, Maja; Zvornicanin, Jasmin (Forthcoming 2023). Gender and Age-Related Differences of Ocular Biometric Parameters in Patients Undergoing Cataract Surgery in Bosnia and Herzegovina [Dataset]. Dryad. https://doi.org/10.5061/dryad.sbcc2fr7r
DATA & FILE OVERVIEW
- File List: Gender_and_Age_Related_Differences_of_Ocular_Biometric_Parameters
- Relationship between files, if important: NONE.
- Additional related data collected that was not included in the current data package: NONE.
- Are there multiple versions of the dataset? NO. A. If yes, name of file(s) that was updated: i. Why was the file updated? ii. When was the file updated?
METHODOLOGICAL INFORMATION
- Description of methods used for collection/generation of data: All biometric measurements were performed using the optical biometer OA-2000 (Tomey, Nagoya, Japan). For measurements of axial length (AL), anterior chamber depth (ACD) and lens thickness (LT), it uses swept-source optical coherence tomography (SS-OCT) with a laser wavelength of 1060 nm.24 It is capable of simultaneously measuring corneal curvature by Placido-disc–based topography techniques with 9 rings each 256 points in a 5.5 mm zone projected onto the cornea.25 For measurement, all subjects were asked to sit in front of the instrument, place their chin in the chinrest, focus on a target, blink completely and keep eyes wide open without blinking during scanning. The device performs the measurements automatically without the need for realignment. Corneal astigmatism was designated as against-the-rule (ATR) when the axis of correcting minus cylinder was within 30° of the vertical 90° meridian, with-the-rule (WTR) when the correcting minus cylinder axis was within 30° of the horizontal 180° meridian, and oblique (OBQ) if it was neither ATR nor WTR orientation. Based on AL all eyes were stratified into 3 groups: shorter than 22.0mm, 22-24.5mm, and longer than 24.5mm.12 Age was stratified into 5 groups: 40-49, 50-59, 60-69, 70-79, and ≥ 80 years of age.8,19 After biometry, all patients underwent a complete ophthalmic examination, including visual acuity testing with Snellen charts, tonometry, detailed slit lamp biomicroscopy, pupillary reaction, and fundoscopy. The inclusion criteria for the current study were the presence of cataract and the age of 40 years or older. The exclusion criteria were dense cataracts that interfered with biometric measurement, ocular surface disorders, previous corneal or intraocular surgery, and a history of intraocular inflammation and penetrating eye trauma.
- Methods for processing the data: Continuous variables were tested for normality using the Shapiro-Wilk test and presented as mean and standard deviation (SD) or, if strongly skewed, additionally as medians and interquartile range (IQR). Differences between continuous variables among different groups were tested using the t-test if normally distributed, while the non-parametric Wilcoxon Mann-Whitney test was used for non-normally distributed variables. Binary and categorical variables are reported as absolute numbers and percentages and are tested for differences using the chi-square test. A rank-based nonparametric Kruskal-Wallis test was applied to determine differences between more than two groups of an independent variable in continuous dependent variables. The correlation was estimated using the pairwise Pearson correlation coefficient. All analyses were performed with Stata version 15.1 (StataCorp, College Station, Texas, USA). The significance level for hypothesis testing was set at 0.05.
- Instrument- or software-specific information needed to interpret the data: The data were analyzed using Stata Statistical Software, version 15.1 (StataCorp LP, College Station, Texas, USA).
- Standards and calibration information, if appropriate: NONE.
- Environmental/experimental conditions: NONE.
- Describe any quality-assurance procedures performed on the data: All data was double checked when data was acquired and entered in excel file.
- People involved with sample collection, processing, analysis and/or submission: Edita Zvorničanin, Zoran Vatavuk, Maja Popović and Jasmin Zvorničanin
DATA-SPECIFIC INFORMATION FOR: [Gender_and_Age_Related_Differences_of_Ocular_Biometric_Parameters]
- Number of variables: 18
- Number of cases/rows: 1278
- Variable List:
- Age - age of included patients at the time of the surgery.
- age_category - Patients were grouped into 5 groups: 40-49, 50-59, 60-69, 70-79, and ≥ 80 years of age.
- Sex - Male (1) or Female (0).
- Side - Right or Left.
- K1 - measured curvature of the steep corneal meridian in D.
- K2 - measured curvature of the flat corneal meridian in D.
- AvgK - average measured corneal curvature in D.
- Cyl - corneal astigmatism measured in D.
- Astaxxcyl - corneal astigmatism angle.
- Asttype - According to the corneal astigmatism angle, the data were classified into three groups: WTR - with the rule, ATR - against the rule and OBQ - oblique.
- Axial - axial length of operated eye measured in millimeters.
- Axial_category - Patients were grouped into two groups based on the axial length: <22.0 mm, 22.0-24.5mm and >24.5 mm.
- Acd - anterior chamber depth of operated eye measured in millimeters.
- Lens - Lens thickness of operated eye measured in millimeters.
- Ioliq - dioptric power of theoretical intraocular lens planned for the surgery.
- ast_1D - measured astigmatism greater than 1D.
- ast_2D - measured astigmatism greater than 2D.
- ast_3D - measured astigmatism greater than 3D.
- Missing data codes: NONE
- Specialized formats or other abbreviations used: NONE
Methods
This was a retrospective cross-sectional study of the eyes of 1278 consecutive patients who underwent cataract surgery in a private tertiary care clinic in Bosnia and Herzegovina, between January 1, 2017, and December 31, 2021. All included patients were citizens of Bosnia and Herzegovina and belong to different ethnic groups. However, there is no major genetic difference between three major ethnic groups in Bosnia and Herzegovina, (Bosniaks, Bosnian Serbs, and Bosnian Croats), indicating that they present the same gene pool. Furthermore, the human population of Bosnia and Herzegovina is closely related to other populations in the Balkans. In patients who underwent surgery on both eyes, we used data for the right eye only. The current study was approved by the institution’s Ethics Committee (Approval number: 01-1-2022). Informed consent was obtained from all patients included in the study at the time of cataract surgery, and the study was conducted according to the Declarations of Helsinki.
All biometric measurements were performed using the optical biometer OA-2000 (Tomey, Nagoya, Japan). For measurements of axial length (AL), anterior chamber depth (ACD) and lens thickness (LT), it uses swept-source optical coherence tomography (SS-OCT) with a laser wavelength of 1060 nm. It is capable of simultaneously measuring corneal curvature by Placido-disc–based topography techniques with 9 rings each 256 points in a 5.5 mm zone projected onto the cornea. For measurement, all subjects were asked to sit in front of the instrument, place their chin in the chinrest, focus on a target, blink completely and keep their eyes wide open without blinking during scanning. The device performs the measurements automatically without the need for realignment.
Corneal astigmatism was designated as against-the-rule (ATR) when the axis of correcting minus cylinder was within 30° of the vertical 90° meridian, with-the-rule (WTR) when the correcting minus cylinder axis was within 30° of the horizontal 180° meridian, and oblique (OBQ) if it was neither ATR nor WTR orientation. Based on AL all eyes were stratified into 3 groups: shorter than 22.0mm, 22–24.5mm, and longer than 24.5mm. Age was stratified into 5 groups: 40–49, 50–59, 60–69, 70–79, and ≥ 80 years of age.
After biometry, all patients underwent a complete ophthalmic examination, including visual acuity testing with Snellen charts, tonometry, detailed slit lamp biomicroscopy, pupillary reaction, and fundoscopy. The inclusion criteria for the current study were the presence of cataract and the age of 40 years or older. The exclusion criteria were dense cataracts that interfered with biometric measurement, ocular surface disorders, previous corneal or intraocular surgery, and a history of intraocular inflammation and penetrating eye trauma.
Continuous variables were tested for normality using the Shapiro-Wilk test and presented as mean and standard deviation (SD) or, if strongly skewed, additionally as medians and interquartile range (IQR). Differences between continuous variables among different groups were tested using the t-test if normally distributed, while the non-parametric Wilcoxon Mann-Whitney test was used for non-normally distributed variables. Binary and categorical variables are reported as absolute numbers and percentages and are tested for differences using the chi-square test. A rank-based nonparametric Kruskal-Wallis test was applied to determine differences between more than two groups of an independent variable in continuous dependent variables. The correlation was estimated using the pairwise Pearson correlation coefficient. All analyses were performed with Stata version 15.1 (StataCorp, College Station, Texas, USA). The significance level for hypothesis testing was set at 0.05.