Data from: Comparison of dopamine release and uptake parameters across sex, species and striatal subregions
Data files
Feb 07, 2024 version files 594.17 KB
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Mouse_Data.xlsx
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Rat_Data.xlsx
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README.md
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Stability_Data.xlsx
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Volt_Baseline_Data.xlsx
May 28, 2024 version files 594.71 KB
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Mouse_Data.xlsx
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Rat_Data.xlsx
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README.md
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Stability_Data.xlsx
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Volt_Baseline_Data.xlsx
Abstract
Dopamine in the striatum strongly regulates behavioral output in a heterogenous across the various striatal subregions. Moreover, dopamine dynamics not only displays heterogeneity across brain structures but also within males and females. The purpose of this dataset was to evaluate the dopamine dynamics in male and female mice and rats across five subregions: the dorsolateral caudate, ventromedial caudate, nucleus accumbens core, nucleus accumbens lateral shell, and the nucleus accumbens medial shell. Fast scan cyclic voltammetry (FSCV) was employed to measure dopamine release and uptake following a single pulse electrical stimulation in each of these subregions within a single brain slice. The dopamine dynamics were also observed across a variety of stimulation amplitudes. The goal of this dataset was to produce systematic FSCV measurements of dopamine across the rodent striatum using FSCV which would be available as a resource for further investigation of DA terminal function.
Methods
Detailed methods can be found in the manuscript.