Skip to main content
Dryad logo

Enhanced and unified anatomical labeling for a common mouse brain atlas

Citation

Chon, Uree; Vanselow, Daniel; Cheng, Keith; Kim, Yongsoo (2019), Enhanced and unified anatomical labeling for a common mouse brain atlas, Dryad, Dataset, https://doi.org/10.5061/dryad.t1g1jwsxw

Abstract

Anatomical atlases in standard coordinates are necessary for the interpretation and integration of research findings in a common spatial context. However, the two most-used mouse brain atlases, the Franklin and Paxinos (FP) and the common coordinate framework (CCF) from the Allen Institute for Brain Science, have accumulated inconsistencies in anatomical delineations and nomenclature, creating confusion among neuroscientists. To overcome these issues, here we adopt the FP labels into the CCF to merge two labels in the single atlas framework. We use cell type specific transgenic mice and an MRI atlas to adjust and further segment our labels. Moreover, detailed segmentations are added to the dorsal striatum using cortico-striatal connectivity data. Lastly, we digitize our anatomical labels based on the Allen ontology, create a web-interface for visualization, and provide tools for comprehensive comparisons between the CCF and FP labels. Our open-source labels signify a key step towards a unified mouse brain atlas.