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Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder

Citation

Ryu, Seunghyong; Lee, Dong-Kyun (2021), Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder, Dryad, Dataset, https://doi.org/10.5061/dryad.t1g1jwt3q

Abstract

This study aimed to investigate different patterns of white matter (WM) abnormalities in patients with psychotic (PBD) and non-psychotic bipolar disorder (NPBD). We used 3T-magnetic resonance imaging to examine 29 PBD, 23 NPBD, and 65 healthy control (HC) subjects. Using tract-based spatial statistics for diffusion tensor imaging data, we compared fractional anisotropy (FA) and mean diffusion (MD) pairwise among the PBD, NPBD, and HC groups. We found several WM areas of decreased FA or increased MD in the PBD and NPBD groups compared to HCs. PBD showed widespread FA decreases in the corpus callosum as well as the bilateral internal capsule and fornix. However, NPBD showed local FA decreases in a part of the corpus callosum body as well as in limited regions within the left cerebral hemisphere, including the anterior and posterior corona radiata and the cingulum. In addition, both PBD and NPBD shared widespread MD increases across the posterior corona radiata, cingulum, and sagittal stratum. These findings suggest that bipolar disorder, regardless of PBD or NPBD, might involve widespread alterations in WM microstructure. In particular, disruptions of inter- and intra- hemispheric WM connectivity, in terms of FA, might be pronounced in PBD.