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Synthesis of novel mesoporous silicate molecular sieves by Aerosol-assisted method for loading and release of drug

Citation

Hao, Liang (2020), Synthesis of novel mesoporous silicate molecular sieves by Aerosol-assisted method for loading and release of drug, Dryad, Dataset, https://doi.org/10.5061/dryad.tmpg4f4w4

Abstract

The novel mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by aerosol-assisted method for loading and release of ibuprofen. The synthesized samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and N2 adsorption-desorption isotherms. The drug ibuprofen was applied as a model drug to investigate the drug release behavior by UV spectrophotometry measurements. The investigation results demonstrate that mesoporous silicate molecular sieves by aerosol-assisted method are spherical with the core-shell structure. As the drug carrier, it has good structural stability and can achieve drug controlled release which is expected. Therefore, the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers.